Only the beginning of the anime and manga are similar. After
in the manga, does the story start dramatically changing. Also, the Nina/Tucker/Scar arc and the Lab 5 arc are both a lot different in the manga as well. This story is nothing like the first anime. This anime is based off of the manga and is the original story by the original creator. Also, episode 3 is out! 
http://animeblogz.com/fullmetal-alchemist-brotherhood-episode-3/
Hughes' death

http://animeblogz.com/fullmetal-alchemist-brotherhood-episode-3/