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Extreme CC spoilers below.
The origins of Angeal and Genesis
Genesis and Angeal are both results of project G(which stands for Gillian). Project G was headed by proffesor Hollander, whose goal was to make an ancient before proffesor Gast and Hojo did.(remeber at the time it was thought Jenova was an ancient). The project started by injecting Jenova cells into a woman named Gillian Hewley. After this they took one of her egg cells, put it into another woman's womb and allowed it to be fertilized and grow. Angeal was made by Hollander having relations with Gillian, and the child was allowed to grow in her womb. Genesis and Angeal both result from this project. Apparently though, there is a flaw in the project because both Genesis and Angeal deteriorate, though Angeal at a much slower rate because he was the best result of project G.
Genesis was initially deemed a failure though because he was born a normal kid. He joined SOLDIER because of Sephiroth, who was someone around his age who had already achieved so much.
About your theory of Zack fighting Angeal.
Zack does end up killing Angeal. Angeal has begun to degenerate into a monster, and he wants to die while he still has his humanity left so he asks Zack to fight him to the death.
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