Okay... I knew this was coming... So here's my list and reasons.
Best Wide-Audience Anime
Naruto is my pick when it comes to the best wide-audience anime. Though the series does have many minor flaws, it has enough humor to please the kiddos while also providing a well-developed story and mature themes for adults.
Best Anime Movie
It's a hard decision for me to choose between Akira and Princess Mononoke... Akira deserves credit for jump-starting the American anime industry, despite the fact that it doesn't match up exactly with the epic manga.
Meanwhile, Princess Mononoke is a gorgeous masterpiece by Hayao Miyazaki. The story is enchanting, as are the characters within, and no one character can be singled out as 'the villain' of the story.
Best Wartime Anime
I'd have to say that this goes to 'Grave of the Fireflies'. While it doesn't take place in the middle of WWII, it does show us life in Japan during that era, and is a captivating, yet tragic tale, sure to summon tears from any serious viewer.
Best Adult Anime
When I think of Animes to fit into this catagory, what pops into my head is Hellsing and Cowboy Bebop. Hellsing is a gothic semi-modern piece about vampires and freaks, violent and edgy to appeal to the more violent fans.
Cowboy Bebop, though also violent, is a Jazz-laced sci-fi adventure, following a strange group of bounty hunters and their dog, Ein. It also has a large amount of comedic moments. Anyone want to 'Mushroom Samba'?
Personal Favorite Animes of All-Time!
Slayers: a fantasy/comedy anime that spans 3 seasons and a number of films.
Lodoss - CotHK: Chronicles of the Heroic Knight is an awesome fantasy/action anime similar to Lord of the Rings, it has awesome characters (Orson the Berzerker is my fave), and every episode ends with a chibi edition of the episode you just saw. Plus, you gotta love the opening theme, haven't seen it in years and it still gets stuck in my head.
Harlock Saga: Leiji Matsumoto was a genius! After watching Harlock Saga, a short series based on his recurring space pirate character, I was longing to see more of what he had to offer.